Our research team is trying to establish the syngas fermentation process for hyper chemical production. First, we design high efficiency gas delivery device to generate micro bubble. Second, the optimized process design is required to increase biocatalyst concentration. Also, we develop mathematical models to quantify physiological characteristics of syngas fermenting microbes and simulate process operational parameters such as chemical concentration, gas consumption and mass transfer rate. Based on the process simulation, techno-economic analysis is conducted.